As human exploration advances beyond low Earth orbit and toward sustained missions to the Moon, Mars, and potentially deeper regions of the solar system, the biological consequences of living outside our planet’s protective environment have become a central scientific priority. Space genomics has emerged at this frontier as a multidisciplinary field investigating how extraterrestrial conditions interact with the human genome at molecular, cellular, and systemic levels. Life on Earth evolved under relatively constant gravitational forces, atmospheric shielding, and geomagnetic protection from high-energy cosmic radiation. In contrast, space environments expose biological systems to chronic microgravity, ionizing radiation, altered magnetic fields, confined habitats, disrupted circadian cycles, and limited ecological diversity. These combined stressors challenge genomic stability and require adaptive responses that extend far beyond ordinary terrestrial physiology. Among these ...